click here to visit website
Search the business directory  

THE QUESTION OF RESISTANCE AND ROTATION

What is resistance? Resistance is "the genetically transmitted loss of sensitivity in (parasite) populations previously sensitive to the same drug."
i.e. strains of small redworm, previously controlled by fenbendazole, are no longer controlled by this drug.

Some useful tips on worm control are as follows:
How can resistance develop? Resistance develops due to artificial selection by wormers. Selection caused by the level of exposure to a wormer and the level of effectiveness that wormer has against a parasite.

· Exposure to wormer: … High frequency of dosing - "too -frequent" treatments with the same molecule of wormer predisposes the parasite to develop resistance. … Under dosing - parasites are exposed to the drug, but not a sufficient dosage to kill them and so they start to build immunity to its effect.

· Effectiveness of wormer: … Wormers that are less than 90% effective against parasite select for resistance as those left behind produce resistant descendants.

To rotate or not rotate
The idea to rotate horse wormers to reduce the risk of resistance is actually derived from sheep farming. However no studies in sheep, let alone horses, have shown that rotation makes a significant difference in the length of time it takes for resistance to occur

As such some experts are now of the opinion that, instead of rotation, a better way to reduce the risk of resistance building up is to:
· Worm less frequently, i.e. use wormers with long dosing intervals
· Not use wormers with known resistance for routine worm control, and
· Not under-dose, but to give your horse the correct dose according to its weight.

Active ingredient of horse wormer Dosing interval Known resistance in the UK
moxidectin (EQUEST) 13 weeks NO
praziquantel (EQUITAPE) 6 months* NO
ivermectin 8-10 weeks NO
ivermectin+praziquantel 8-10 weeks NO
pyrantel 4-8 weeks Yes, reported resistance in small and large redworms1
fenbendazole 6-8 weeks Yes, widespread small redworm resistance
*Treatment for tapeworm recommended in the spring and autumn. 1. Coles G C et al 1999, Veterinary Record, 145: 408

Suggested worming programme Together EQUEST and EQUITAPE offer a comprehensive, effective and simple worm control programme.

A programme that does not require a 5 day course for the control of encysted small redworm, nor a double dose for the control of tapeworm. Plus a programme which fulfils the requirement to reduce the risk of resistance building up, with long dosing intervals for EQUEST (every 13 weeks) and EQUITAPE (6 months) and no known resistance to either wormer.

As such a programme from which there is no need to rotate off, but one you can stick to using year-on-year**. Now doesn't that make worming your horse simple!

  Spring Summer Autumn Winter
Routine roundworm (including all stages of encysted small redworm) and bot control EQUEST (single dose every 13 weeks) EQUEST (single dose every 13 weeks) EQUEST (single dose every 13 weeks) EQUEST (single dose every 13 weeks)
Tapeworm control EQUITAPE (single dose)   EQUITAPE (single dose)  

** Variability in worm challenge and susceptibility does occur and your veterinary surgeon should be contacted for specific advice. As with any preventative medicine programme periodic assessment is advisable.

For further information on worming plus a free worming calendar, call the EQUEST/EQUITAPE literature hotline on 01489 774232.
Or visit:-
www.wormingyourhorse.info